Link an oligonucleotide with another molecule or a particular surface. Subcategories include biotins, amino-modifiers, alkynes, and thiol Modifiers, as well as Azide, Digoxigenin, and Cholesterol-TEG.
Fluorescent dyes re-emit light upon excitation while dark quenchers absorb the emitted light and release heat. These modifications are added to oligos that are used in a variety of molecular biology applications. Browse our Freedom™ Dyes, which have no patent licensing restrictions, or the full catalog of fluorophores and dark quenchers.
A variety of modifications that can serve a range of functions, including cross-linking, duplex stabilization, and nuclease resistance.
Use if your oligo is being used as a substrate for DNA ligase. 3′ phosphorylation will inhibit degradation by some 3′ exonucleases and can be used to block extension by DNA polymerase.
Create distance between a functional moiety and the hybridizing region of your oligo. This category includes the commonly used C3 Spacer, as well as Spacer 9, Spacer 18, and dSpacer.
Learn about the two-step process that uses quantitative chemical reactions of alkyne and azide moieties to create covalent carbon-heteroatom bonds between biochemical species. See available modifications.
Include these bonds in your oligo sequence for increased inter-nucleotide resistance to nuclease degradation. These modified bonds are especially beneficial when incorporated into antisense oligos.