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Large-scale synthesis

  • Obtain high purity DNA and RNA oligos in bulk quantities with competitive pricing and turnaround times
  • Consult and collaborate with our experts to determine the best solutions for your projects from pilot to commercial-scale production
  • Focus on commercialization efforts and allow us to manufacture to your exact specifications with custom QC, processing, and documentation

Manufacturing capabilities

Numerous collaborations with our customers have enabled us to optimize our manufacturing processes and platforms for bulk synthesis of various types of oligos. Our large-scale capabilities range from standard, unmodified oligos to highly complex oligos for high-throughput, diagnostic, and other commercial applications. You can acquire milligram to gram quantities of highly pure nucleic acids, including aptamers, ribozymes, miRNAs and siRNAs, next generation sequencing adapters, PCR primers, and dual-labeled probes.

Additional features of our large-scale offerings include:

  • Final yields from 25 mg to 10 g
  • Standard DNA and RNA bases, modified bases, chemical modifications, linkers, and fluorophores
  • Unmodified DNA lengths between 4–100 bases
  • Unmodified RNA lengths between 4–70 bases
  • GMP manufacturing available for customers requiring controlled processes and traceability
  • Turnaround times with delivery in as few as 10 business days

Additional services

In addition to using industry-leading oligos, when you work with our team of large-scale experts you will benefit from a variety of personalized services. These include:

  • Confidential, application-specific guidance for your transition from small- to large-scale production
  • Flexible ordering methods
  • Custom purification options and purity specifications
  • Formulation services for the creation of oligo pools, primer mixes, assays, and duplexes
  • Custom vialing and plating options with consistent or variable fill sizes
  • Verification and release of product compliance before shipment
  • Hard-copy analytical QC documentation and certificates of analysis

To learn more about these individual services, click here.

PrimerQuest Tool

Allows highly customized designs for PCR primers and qPCR assays

OligoAnalyzer tool

Identify oligonucleotide properties, including melting temperature, hairpins, dimers and mismatches

UNAFold tool

Perform secondary structure analysis

Dilution Calculator

Find the volume needed to dilute your oligo stock to a lower concentration

Resuspension Calculator

Find the volume needed to resuspend a dry oligo to a desired concentration

GMP

Our GMP products and services are customized to your exact specifications with the required documentation required for components used in clinical and molecular diagnostic applications. To learn more about our GMP capabilities, click here.